New Castle Bible Church has a vibrant emphasis on global mission endeavors. Global missions has been a passionate part of the church for many years in light of Jesus' command to "go into all the world and make disciples."
Currently, the church partners with eighteen different missionaries across the globe in their work of sharing the Good News of Jesus Christ. New Castle Bible Church also sends short-term teams to encourage and support these missionaries. Trips in recent years inlcude students and parents going on mission trips to Nigeria and Ecuador, trips to various countries in Africa, as well as medical mission trips to Ecuador.